Dexamethasone priming enhances stemness and immunomodulatory property of tissue-specific human mesenchymal stem cells.

ABSTRACT:

Background

Human Mesenchymal Stem Cells (hMSCs) represent a promising cell source for cell-based therapy in autoimmune diseases and other degenerative disorders due to their immunosuppressive, anti-inflammatory and regenerative potentials. Belonging to a glucocorticoid family, Dexamethasone (Dex) is a powerful anti-inflammatory compound that is widely used as therapy in autoimmune disease conditions or allogeneic transplantation. However, minimal immunomodulatory effect of hMSCs may limit their therapeutic uses. Moreover, the effect of glucocorticoids on the immunomodulatory molecules or other regenerative properties of tissue-specific hMSCs remains unknown.

Method

Herein, we evaluated the in vitro effect of Dex at various dose concentrations and time intervals, 1000 ng/ml,

SUBMITTER: Rawat S 

PROVIDER: S-EPMC8567134 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature