Comprehensive Analysis of IGFBPs as Biomarkers in Gastric Cancer.

ABSTRACT:

Objective

Gastric cancer is the fifth most common cancer worldwide and the third leading cause of cancer-related deaths. Insulin-like growth-factor-binding proteins (IGFBPs) were initially identified as passive inhibitors that combined with insulin-like growth factors (IGFs) in serum. However, more recent data have shown that they have different expression patterns and a variety of functions in the development and occurrence of cancers. Thus, their various roles in cancer still need to be elucidated. This study aimed to explore the IGFBPs and their prognostic value as markers in gastric cancer.

Methods

Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier Plotter, cBioPortal, GeneMANIA, and TIMER were used to analyze the differential expression, prog

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8567138 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature