Radiation Plus Anti-PD-1 Therapy for NSCLC Brain Metastases: A Retrospective Study.

ABSTRACT:

Background

Radiation therapy (RT) is the mainstay of brain metastases (BMs), and anti-PD-1 blockade has led to intracranial responses in non-small cell lung carcinoma (NSCLC) patients with BMs.

Objective

This study aimed to evaluate the efficacy and safety of adding anti-PD-1 blockade to RT in the management of NSCLC patients with BM in terms of survival outcome.

Materials and methods

We retrospectively reviewed 70 NSCLC patients with BMs who were treated with whole brain radiation therapy (WBRT) between January 2016 and January 2021. Of the 70 patients, 29 additionally received anti-PD-1 therapy within 30 days of WBRT initiation. Baseline characteristics of the patients and efficacy outcomes such as progression-free survival (PFS) and overall survival (OS) were stati

SUBMITTER: Liao G 

PROVIDER: S-EPMC8567143 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature