L-Type Ca²⁺ Channels of NG2 Glia Determine Proliferation and NMDA Receptor-Dependent Plasticity.

ABSTRACT: NG2 (nerve/glial antigen 2) glia are uniformly distributed in the gray and white matter of the central nervous system (CNS). They are the major proliferating cells in the brain and can differentiate into oligodendrocytes. NG2 glia do not only receive synaptic input from excitatory and inhibitory neurons, but also secrete growth factors and cytokines, modulating CNS homeostasis. They express several receptors and ion channels that play a role in rapidly responding upon synaptic signals and generating fast feedback, potentially regulating their own properties. Ca²⁺ influx via voltage-gated Ca²⁺ channels (VGCCs) induces an intracellular Ca²⁺ rise initiating a series of cellular activities. We confirmed that NG2 glia express L-type VGCCs in the white and

SUBMITTER: Zhao N 

PROVIDER: S-EPMC8567174 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature