Association of KRAS Variant Subtypes With Survival and Recurrence in Patients With Surgically Treated Intrahepatic Cholangiocarcinoma.

ABSTRACT:

Importance

KRAS variants are associated with tumor progression; however, the prevalence of KRAS variant subtypes and their association with survival and recurrence in patients with intrahepatic cholangiocarcinoma (ICC) after curative resection are largely unknown.

Objective

To explore the prognostic association of KRAS variant subtypes with survival and recurrence in patients with ICC.

Design, setting, and participants

In this cohort study, patients who underwent curative resection for ICC from January 2009 through December 2016 at a single hospital in China were recruited, and whole-exome sequencing, targeted sequencing, and Sanger sequencing were performed to identify KRAS variants. Kaplan-Meier and log-rank tests were used to compare overall survival (OS) and disea

SUBMITTER: Zhou SL 

PROVIDER: S-EPMC8567187 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature