SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation.

ABSTRACT: Neuroinflammation is a common feature of many neurodegenerative diseases. It fosters a dysfunctional neuron-microglia-astrocyte crosstalk that, in turn, maintains microglial cells in a perniciously reactive state that often enhances neuronal damage. The molecular components that mediate this critical communication are not fully explored. Here, we show that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, is part of the cellular crosstalk underlying neuroinflammation. In mouse models of acute and chronic neuroinflammation, SFRP1, largely astrocyte-derived, promotes and sustains microglial activation, and thus a chronic inflammatory state. SFRP1 promotes the upregulation of components of the hypoxia-induced factor-dependent inflammatory

SUBMITTER: Rueda-Carrasco J 

PROVIDER: S-EPMC8567217 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature