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Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.

ABSTRACT: A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os₃(CO)₁₀(μ-H)[μ-SC₆H₄-p-B(OH)₂]} (2) could be chemically oxidized to its hydroxy analogue [Os₃(CO)₁₀(μ-H)(μ-SC₆H₄ -p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.

SUBMITTER: Kong JW

PROVIDER: S-EPMC8567370 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

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Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.

Kong Jia Wen JW Lam Zhiyong Z Chan Kiat Hwa KH Ganguly Rakesh R Joey Lee Jia-Ying JY Loo Lit-Hsin LH Webster Richard D RD Wong Zhen Xuan ZX Leong Weng Kee WK

ACS omega 20211022 43

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os<sub>3</sub>(CO)<sub>10</sub>(μ-H)[μ- ...[more]

PMID: 34746593

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