Ontology highlight
ABSTRACT:
SUBMITTER: Staller E
PROVIDER: S-EPMC8567425 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Staller Ecco E Sheppard Carol M CM Baillon Laury L Frise Rebecca R Peacock Thomas P TP Sancho-Shimizu Vanessa V Barclay Wendy S WS
The Journal of general virology 20210901 9
Viruses require host factors to support their replication, and genetic variation in such factors can affect susceptibility to infectious disease. Influenza virus replication in human cells relies on ANP32 proteins, which are involved in assembly of replication-competent dimeric influenza virus polymerase (FluPol) complexes. Here, we investigate naturally occurring single nucleotide variants (SNV) in the human <i>Anp32A</i> and <i>Anp32B</i> genes. We note that variant rs182096718 in <i>Anp32B</i ...[more]