Alternative RNA splicing in stem cells and cancer stem cells: Importance of transcript-based expression analysis.

ABSTRACT: Alternative ribonucleic acid (RNA) splicing can lead to the assembly of different protein isoforms with distinctive functions. The outcome of alternative splicing (AS) can result in a complete loss of function or the acquisition of new functions. There is a gap in knowledge of abnormal RNA splice variants promoting cancer stem cells (CSCs), and their prospective contribution in cancer progression. AS directly regulates the self-renewal features of stem cells (SCs) and stem-like cancer cells. Notably, octamer-binding transcription factor 4A spliced variant of octamer-binding transcription factor 4 contributes to maintaining stemness properties in both SCs and CSCs. The epithelial to mesenchymal transition pathway regulates the AS events in CSCs to maintain stemness. The alternative spliced

SUBMITTER: Ebrahimie E 

PROVIDER: S-EPMC8567453 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature