Global absence and targeting of protective immune states in severe COVID-19.

ABSTRACT: Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals^1-3, many others experience milder symptoms. Here, to gain a more comprehensive understanding of the distinction between severe and mild phenotypes in the pathology of coronavirus disease 2019 (COVID-19) and its origins, we performed a whole-blood-preserving single-cell analysis protocol to integrate contributions from all major immune cell types of the blood-including neutrophils, monocytes, platelets, lymphocytes and the contents of the serum. Patients with mild COVID-19 exhibit a coordinated pattern of expression of interferon-stimulated genes (ISGs)³ across every cell population, whereas these ISG-expressing cells are systemi

SUBMITTER: Combes AJ 

PROVIDER: S-EPMC8567458 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature