Sex without crossing over in the yeast Saccharomycodes ludwigii.

ABSTRACT:

Background

Intermixing of genomes through meiotic reassortment and recombination of homologous chromosomes is a unifying theme of sexual reproduction in eukaryotic organisms and is considered crucial for their adaptive evolution. Previous studies of the budding yeast species Saccharomycodes ludwigii suggested that meiotic crossing over might be absent from its sexual life cycle, which is predominated by fertilization within the meiotic tetrad.

Results

We demonstrate that recombination is extremely suppressed during meiosis in Sd. ludwigii. DNA double-strand break formation by the conserved transesterase Spo11, processing and repair involving interhomolog interactions are required for normal meiosis but do not lead to crossing over. Although the species has retained an intact

SUBMITTER: Papaioannou IA 

PROVIDER: S-EPMC8567612 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature