Hypoxia-inducible factor-1α expression and breast cancer recurrence in a Danish population-based case control study.

ABSTRACT:

Background

Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that facilitates the adaptation of cancer cells to hypoxic conditions and may be prognostic of breast cancer recurrence. We evaluated the association of HIF-1α expression with breast cancer recurrence, and its association with timing of breast cancer recurrence.

Methods

In this population-based case-control study, we included women diagnosed with stage I-III breast cancer between 1985 and 2001, aged 35-69 years, registered in the Danish Breast Cancer Group. We identified 541 cases of breast cancer recurrence among women with estrogen receptor (ER)-positive disease who were treated with tamoxifen for at least 1 year (ER+ TAM+). We also enrolled 300 breast cancer recurrence cases among women with ER-nega

SUBMITTER: Collin LJ 

PROVIDER: S-EPMC8567651 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature