Epigenetic adaptations of the masticatory mucosa to periodontal inflammation.

ABSTRACT:

Background

In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammation. Epigenetic modifications of the chromatin confer plasticity to the genetic information and give insight into how tissues use the genetic information to adapt to environmental factors. The oral mucosa is particularly exposed to environmental stressors such as a variable microbiota. Likewise, persistent oral inflammation is the most important intrinsic risk factor for the oral inflammatory disease periodontitis and has strong potential to alter DNA-methylation patterns. The aim of the current study was to identify epigenetic changes of the oral masticatory mucosa

SUBMITTER: Richter GM 

PROVIDER: S-EPMC8567676 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature