The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia.

ABSTRACT:

Background

Vaginal microbiota (VMB) composition is altered in women with cervical intra-epithelial neoplasia (CIN) compared to healthy controls and is associated with disease progression. However, the impact of CIN excision on the VMB and innate immunity is not known. This observational study aims to explore the impact of CIN excision on the VMB, antimicrobial peptides (AMP) and proinflammatory cytokines.

Methods

We sampled 103 non-pregnant, premenopausal women at the time of excisional treatment for CIN and at their 6-month follow-up visit. A further 39 untreated controls with normal cytology were also sampled. We used metataxonomics to group vaginal swab samples into community state types (CSTs) and ELISA to quantify cytokine and AMP levels in matched vaginal secretions. A

SUBMITTER: Mitra A 

PROVIDER: S-EPMC8567681 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature