Enhancer analysis of the Drosophila zinc finger transcription factor Earmuff by gene targeting.

ABSTRACT:

Background

Many transcription factors are involved in the formation of the brain during the development of Drosophila melanogaster. The transcription factor Earmuff (Erm), a member of the forebrain embryonic zinc finger family (Fezf), is one of these important factors for brain development. One major function of Earmuff is the regulation of proliferation within type II neuroblast lineages in the brain; here, Earmuff is expressed in intermediate neural progenitor cells (INPs) and balances neuronal differentiation versus stem cell maintenance. Erm expression during development is regulated by several enhancers.

Results

In this work we show a functional analysis of erm and some of its enhancers. We generated a new erm mutant allele by gene targeting and reintegrated Gal4 to mak

SUBMITTER: Hildebrandt K 

PROVIDER: S-EPMC8567707 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature