One-photon red light-triggered disassembly of small-molecule nanoparticles for drug delivery.

ABSTRACT:

Background

Photoresponsive drug delivery can achieve spatiotemporal control of drug accumulation at desired sites. Long-wavelength light is preferable owing to its deep tissue penetration and low toxicity. One-photon upconversion-like photolysis via triplet-triplet energy transfer (TTET) between photosensitizer and photoresponsive group enables the use of long-wavelength light to activate short-wavelength light-responsive groups. However, such process requires oxygen-free environment to achieve efficient photolysis due to the oxygen quenching of triplet excited states.

Results

Herein, we report a strategy that uses red light to trigger disassembly of small-molecule nanoparticles by one-photon upconversion-like photolysis for cancer therapy. A photocleavable trigonal molecule

SUBMITTER: Long K 

PROVIDER: S-EPMC8567723 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature