Multiscale dynamic mean field (MDMF) model relates resting-state brain dynamics with local cortical excitatory-inhibitory neurotransmitter homeostasis.

ABSTRACT: Previous computational models have related spontaneous resting-state brain activity with local excitatory-inhibitory balance in neuronal populations. However, how underlying neurotransmitter kinetics associated with E-I balance govern resting-state spontaneous brain dynamics remains unknown. Understanding the mechanisms by virtue of which fluctuations in neurotransmitter concentrations, a hallmark of a variety of clinical conditions, relate to functional brain activity is of critical importance. We propose a multiscale dynamic mean field (MDMF) model-a system of coupled differential equations for capturing the synaptic gating dynamics in excitatory and inhibitory neural populations as a function of neurotransmitter kinetics. Individual brain regions are modeled as population of MDMF and ar

SUBMITTER: Naskar A 

PROVIDER: S-EPMC8567829 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature