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Neuronal classification from network connectivity via adjacency spectral embedding.

ABSTRACT: This work presents a novel strategy for classifying neurons, represented by nodes of a directed graph, based on their circuitry (edge connectivity). We assume a stochastic block model (SBM) in which neurons belong together if they connect to neurons of other groups according to the same probability distributions. Following adjacency spectral embedding of the SBM graph, we derive the number of classes and assign each neuron to a class with a Gaussian mixture model-based expectation maximization (EM) clustering algorithm. To improve accuracy, we introduce a simple variation using random hierarchical agglomerative clustering to initialize the EM algorithm and picking the best solution over multiple EM restarts. We test this procedure on a large (≈2¹²-2¹⁵ neurons), sparse, biologically inspired connectome with eight neuron classes. The simulation results demonstrate that the proposed approach is broadly stable to the choice of embedding dimension, and scales extremely well as the number of neurons in the network increases. Clustering accuracy is robust to variations in model parameters and highly tolerant to simulated experimental noise, achieving perfect classifications with up to 40% of swapped edges. Thus, this approach may be useful to analyze and interpret large-scale brain connectomics data in terms of underlying cellular components.

SUBMITTER: Mehta K

PROVIDER: S-EPMC8567830 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Neuronal classification from network connectivity via adjacency spectral embedding.

Mehta Ketan K Goldin Rebecca F RF Marchette David D Vogelstein Joshua T JT Priebe Carey E CE Ascoli Giorgio A GA

Network neuroscience (Cambridge, Mass.) 20210830 3

This work presents a novel strategy for classifying neurons, represented by nodes of a directed graph, based on their circuitry (edge connectivity). We assume a stochastic block model (SBM) in which neurons belong together if they connect to neurons of other groups according to the same probability distributions. Following adjacency spectral embedding of the SBM graph, we derive the number of classes and assign each neuron to a class with a Gaussian mixture model-based expectation maximization ( ...[more]

PMID: 34746623

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Project description:The validity and reliability of diagnoses in psychiatry is a challenging topic in mental health. The current mental health categorization is based primarily on symptoms and clinical course and is not biologically validated. Among multiple ongoing efforts, neurological observations alongside clinical evaluations are considered to be potential solutions to address diagnostic problems. The Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) has published multiple papers attempting to reclassify psychotic illnesses based on biological rather than symptomatic measures. However, the effort to investigate the relationship between this new categorization approach and other neuroimaging techniques, including resting-state fMRI data, is still limited. This study focused on investigating the relationship between different psychotic disorders categorization methods and resting-state fMRI-based measures called dynamic functional network connectivity (dFNC) using state-of-the-art artificial intelligence (AI) approaches. We applied our method to 613 subjects, including individuals with psychosis and healthy controls, which were classified using both the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and the B-SNIP biomarker-based (Biotype) approach. Statistical group differences and cross-validated classifiers were performed within each framework to assess how different categories. Results highlight interesting differences in occupancy in both DSM-IV and Biotype categorizations compared to healthy individuals, which are distributed across specific transient connectivity states. Biotypes tended to show less distinctiveness in occupancy level and included fewer cellwise differences. Classification accuracy obtained by DSM-IV and Biotype categories were both well above chance. Results provided new insights and highlighted the benefits of both DSM-IV and biology-based categories while also emphasizing the importance of future work in this direction, including employing further data types.

Dataset Information

Neuronal classification from network connectivity via adjacency spectral embedding.

Publications

Neuronal classification from network connectivity via adjacency spectral embedding.

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