Changes in the urinary proteome in rats with regular swimming exercise.

ABSTRACT:

Purpose

Urine can sensitively reflect early pathophysiological changes in the body. The purpose of this study was to explore the changes of urine proteome in rats with regular swimming exercise.

Methods

In this study, experimental rats were subjected to daily moderate-intensity swimming exercise for 7 weeks. Urine samples were collected at weeks 2, 5, and 7 and were analyzed by using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).

Results

Unsupervised clustering analysis of all urinary proteins identified at week 2 showed that the swimming group was distinctively different from the control group. Compared to the control group, a total of 112, 61 and 44 differential proteins were identified in the swimming group at weeks 2, 5 and 7, respectively

SUBMITTER: Meng W 

PROVIDER: S-EPMC8567855 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature