Dopaminergic and Cholinergic Modulation of Large Scale Networks in silico Using Snudda.

ABSTRACT: Neuromodulation is present throughout the nervous system and serves a critical role for circuit function and dynamics. The computational investigations of neuromodulation in large scale networks require supportive software platforms. Snudda is a software for the creation and simulation of large scale networks of detailed microcircuits consisting of multicompartmental neuron models. We have developed an extension to Snudda to incorporate neuromodulation in large scale simulations. The extended Snudda framework implements neuromodulation at the level of single cells incorporated into large-scale microcircuits. We also developed Neuromodcell, a software for optimizing neuromodulation in detailed multicompartmental neuron models. The software adds parameters within

SUBMITTER: Frost Nylen J 

PROVIDER: S-EPMC8568057 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature