Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case-control study and meta-analysis.

ABSTRACT:

Background

Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained.

Objective

This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA.

Methods

Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren-Lawrence grading system was used to identify the knee

SUBMITTER: Wang CC 

PROVIDER: S-EPMC8568107 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature