NanoMethViz: An R/Bioconductor package for visualizing long-read methylation data.

ABSTRACT: A key benefit of long-read nanopore sequencing technology is the ability to detect modified DNA bases, such as 5-methylcytosine. The lack of R/Bioconductor tools for the effective visualization of nanopore methylation profiles between samples from different experimental groups led us to develop the NanoMethViz R package. Our software can handle methylation output generated from a range of different methylation callers and manages large datasets using a compressed data format. To fully explore the methylation patterns in a dataset, NanoMethViz allows plotting of data at various resolutions. At the sample-level, we use dimensionality reduction to look at the relationships between methylation profiles in an unsupervised way. We visualize methylation profiles of classes of features such as gen

SUBMITTER: Su S 

PROVIDER: S-EPMC8568149 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature