Osteoblast-osteoclast co-cultures: A systematic review and map of available literature.

ABSTRACT: Drug research with animal models is expensive, time-consuming and translation to clinical trials is often poor, resulting in a desire to replace, reduce, and refine the use of animal models. One approach to replace and reduce the use of animal models is to use in vitro cell-culture models. To study bone physiology, bone diseases and drugs, many studies have been published using osteoblast-osteoclast co-cultures. The use of osteoblast-osteoclast co-cultures is usually not clearly mentioned in the title and abstract, making it difficult to identify these studies without a systematic search and thorough review. As a result, researchers are all developing their own methods, leading to conceptually similar studies with many methodological differences and, as a consequence, incomparable results.

SUBMITTER: Remmers SJA 

PROVIDER: S-EPMC8568160 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature