Circulatory microRNA expression profile for coronary artery calcification in chronic kidney disease patients.

ABSTRACT:

Background & aim

Coronary artery disease (CAD) is the primary cause of mortality in patients with end stage renal disease (ESRD). MicroRNA profiling is proven as a powerful tool in the diagnosis of any disease at the molecular level. Hence, the present study aimed to profile the microRNA expression for CAD especially coronary artery calcification in CKD patients.

Materials and methods

Two hundread patients with CKD stages 3 to 5 without dialysis and healthy controls were included in this study. All two hundred patients underwent 1024 multi sliceardiac computed tomography (CT) scan for calcium scoring. The calcium scoring more than 100 have been included in the study. We performed miRNA microarray analysis from serum samples of seven high calcium scored with CKD patients and

SUBMITTER: Vijayaraghavan B 

PROVIDER: S-EPMC8568233 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature