Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy.

ABSTRACT: Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Traditional Chinese Medicine (TCM). According to the relevant theory, we first carefully collected and screened the active ingredients in ZSS and received 11 active ingredients that may work. The targets going along with these active components were also strongly related to insomnia targets, 108 common genes were identified, and drug-compound-gene symbol-disease visualization network and protein-protein interaction network were constructed. Forty-eight core genes were identified by PPI analysis an

SUBMITTER: Feipeng G 

PROVIDER: S-EPMC8568550 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature