Improving CPMG liver iron estimates with a T1 -corrected proton density estimator.

ABSTRACT:

Purpose

CPMG spin echo acquisitions are attractive for diagnosing and monitoring liver iron concentration in iron overload disorders due to their time efficiency and potential to reveal unique information about tissue iron distribution. Clinical adoption remains low due to the insensitivity of CPMG-based R2 estimates to liver iron concentration (LIC) when common fitting techniques are applied. In this work, we demonstrate that the inclusion of a proton density estimator (PDE) derived from the CPMG acquisition increase the sensitivity of CPMG R2 estimates to LIC in both simulated and in-vivo human data.

Theory and methods

CPMG R2 acquisitions from 50 clinically indicated MRI studies in patients with iron overload were analyzed with and without PDE constraints. Liver regions o

SUBMITTER: Doyle EK 

PROVIDER: S-EPMC8568631 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature