Nucleus basalis of Meynert damage and cognition in patients with multiple sclerosis.

ABSTRACT:

Background

The nucleus basalis of Meynert (NBM), representing the major source of cerebral cholinergic innervations, is vulnerable to neurodegeneration in Alzheimer's and Parkinson's disease.

Objective

To determine associations between NBM properties and cognitive outcomes in patients with multiple sclerosis (PwMS).

Methods

84 PwMS and 19 controls underwent 3T MRI, the Paced Auditory Serial Addition Test (PASAT) and subtests of the Brief International Cognitive Assessment for MS (BICAMS). NBM volume, fractional anisotropy, mean diffusivity (MD), axial diffusivity and radial diffusivity (D_⊥) were calculated. Analyses assessed relationships between cognition and NBM measures. Linear regressions evaluated the prognostic value of baseline measures in predicting

SUBMITTER: Hildesheim FE 

PROVIDER: S-EPMC8568637 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature