Method for fast lipid reconstruction and removal processing in ¹ H MRSI of the brain.

ABSTRACT:

Purpose

To develop a new rapid spatial filtering method for lipid removal, fast lipid reconstruction and removal processing (FLIP), which selectively isolates and removes interfering lipid signals from outside the brain in a full-FOV 2D MRSI and whole-brain 3D echo planar spectroscopic imaging (EPSI).

Theory and methods

FLIP uses regularized least-squares regression based on spatial prior information from MRI to selectively remove lipid signals originating from the scalp and measure the brain metabolite signals with minimum cross contamination. FLIP is a noniterative approach, thus allowing a rapid processing speed, and uses only spatial information without any spectral priors. The performance of FLIP was compared with the Papoulis-Gerchberg algorithm (PGA), Hankel singular

SUBMITTER: Adany P 

PROVIDER: S-EPMC8568649 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature