Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent against Plasmodium chabaudi infection in the mouse liver.

ABSTRACT: In recent years, the use of plant-mediated nanoparticle synthesis to combat infectious diseases has become increasingly significant. Malaria is one of the world's most infectious diseases caused by Plasmodium species. The antioxidant, anti-apoptotic, and anti-inflammatory properties of nanosilver biosynthesized from Indigofera oblongifolia leaf extracts (NS) against Plasmodium chabaudi infection of the mouse liver were investigated in this research. Male mice were infected with P. chabaudi infected erythrocytes then treated with NS for 7 days. The parasitemia was suppressed by approximately 24, 28, 47 and 75% on days 4, 5, 6 and 7 postinfection, respectively after treatment of mice with NS. Also, NS was able to regulate the leucocytes count and the IL1β a

SUBMITTER: Dkhil MA 

PROVIDER: S-EPMC8568723 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature