DNA methylation in former extremely low birth weight newborns: association with cardiovascular and endocrine function.

ABSTRACT:

Background

There is increased risk of cardiovascular, metabolic, and hypertensive disorders in later life in the preterm population. We studied school-age children who had been born extremely premature who had undergone endocrine, cardiovascular, and anthropometric evaluations.

Methods

School age measurements of salivary cortisol, adrenal androgens, blood pressure, and anthropometric markers were correlated with DNA methylation of 11-betahydroxysteroid dehydrogenase type 2 (11BHSD2), leptin, and the LINE1 repetitive DNA element.

Results

We observed a modest correlation between log AUC for salivary cortisol and methylation of leptin in preterm infants and a negative correlation between methylation of region 1 of the glucocorticoid receptor (GR in term-born infants. The

SUBMITTER: Padbury JF 

PROVIDER: S-EPMC8568736 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature