Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8⁺ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function.

ABSTRACT: IL-1β plays critical roles in the priming and effector phases of immune responses such as the differentiation, commitment, and memory formation of T cells. In this context, several reports have suggested that the IL-1β signal is crucial for CTL-mediated immune responses to viral infections and tumors. However, little is known regarding whether IL-1β acts directly on CD8⁺ T cells and what the molecular mechanisms underlying expression of IL-1 receptors (IL-1Rs) on CD8⁺ T cells and features of IL-1R⁺CD8⁺ T cells are. Here, we provide evidence that the expression of IL-1R type I (IL-1RI), the functional receptor of IL-1β, is preferentially induced by IL-21 on TCR-stimulated CD8⁺ T cells. Further, IL-1β enhances the effector function of CD

SUBMITTER: Kim DH 

PROVIDER: S-EPMC8568912 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature