Inflammatory Endotypes and Tissue Remodeling Features in Antrochoanal Polyps.

ABSTRACT:

Purpose

The pathogenic mechanisms of antrochoanal polyps (ACPs) remain largely unknown. This study aimed to characterize inflammatory patterns and tissue remodeling features in ACPs.

Methods

Inflammatory cell infiltration and tissue edema severity as well as fibrin deposition in ACPs and bilateral eosinophilic and noneosinophilic nasal polyps (NPs) were studied with immunohistochemical and immunofluorescence staining. Cytokine levels in sinonasal tissues were detected with the Bio-Plex assay. The expression of coagulation and fibrinolytic markers was measured using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assays.

Results

Compared to control tissues and bilateral eosinophilic and noneosinophilic NPs, ACPs had higher levels of neut

SUBMITTER: Chen CL 

PROVIDER: S-EPMC8569026 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature