Desmoglein 2 regulates cardiogenesis by restricting hematopoiesis in the developing murine heart.

ABSTRACT: Cardiac morphogenesis relies on intricate intercellular signaling. Altered signaling impacts cardiac function and is detrimental to embryonic survival. Here we report an unexpected regulatory role of the desmosomal cell adhesion molecule desmoglein 2 (Dsg2) on murine heart development. A large percentage of Dsg2-mutant embryos develop pericardial hemorrhage. Lethal myocardial rupture is occasionally observed, which is not associated with loss of cardiomyocyte contact but with expansion of abnormal, non-myocyte cell clusters within the myocardial wall. Two types of abnormal cell clusters can be distinguished: Type A clusters involve endocard-associated, round-shaped CD31⁺ cells, which proliferate and invade the myocardium. They acquire Runx1- and CD44-positivity indicating a shif

SUBMITTER: Moazzen H 

PROVIDER: S-EPMC8569146 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature