Desiccation-induced fibrous condensation of CAHS protein from an anhydrobiotic tardigrade.

ABSTRACT: Anhydrobiosis, one of the most extensively studied forms of cryptobiosis, is induced in certain organisms as a response to desiccation. Anhydrobiotic species has been hypothesized to produce substances that can protect their biological components and/or cell membranes without water. In extremotolerant tardigrades, highly hydrophilic and heat-soluble protein families, cytosolic abundant heat-soluble (CAHS) proteins, have been identified, which are postulated to be integral parts of the tardigrades' response to desiccation. In this study, to elucidate these protein functions, we performed in vitro and in vivo characterizations of the reversible self-assembling property of CAHS1 protein, a major isoform of CAHS proteins from Ramazzottius varieornatus, using a series of spectroscopic and micro

SUBMITTER: Yagi-Utsumi M 

PROVIDER: S-EPMC8569203 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature