Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study.

ABSTRACT:

Background

Previous studies indicated the calcium-binding protein S100A12 to be involved in the pathophysiology of pulmonary inflammatory diseases. However, the role of S100A12 has remained elusive in patients with community-acquired pneumonia (CAP). Therefore, the purpose of this prospective cohort study was to evaluate the association between serum S100A12 with severity and prognosis in CAP patients.

Methods

Two groups with either 239 CAP patients or 239 healthy controls were enrolled in our study. Fasting blood and clinical characteristics were collected. On admission, serum S100A12 was measured using enzyme-linked immunosorbent assay (ELISA).

Results

Serum S100A12 was increased in CAP patients compared to control subjects. Furthermore, serum S100A12 was elevated a

SUBMITTER: Jiang X 

PROVIDER: S-EPMC8569229 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature