Physiological Dysregulation, Frailty, and Impacts on Adverse Health and Functional Outcomes.

ABSTRACT: Background: Multi-system physiological dysregulation (PD) may represent a biological endo-phenotype of clinical frailty. We investigated the co-occurrence of PD with physical frailty and its contributions to the known impact of frailty on adverse health outcomes. Methods: Data of 2,725 participants from the Singapore Longitudinal Aging Studies (SLAS-2), included baseline measures of physical frailty and PD derived from Mahalanobis distance (Dm) value of 23 blood biomarkers. We analyzed their concurrent association and their impacts on 9-year mortality, MMSE cognition, GDS depression, number of medications, disability, and hospitalization at baseline and follow up (mean 4.5 years). Results: Global PD (Log₁₀Dm, mean = 1.24, SD = 0.24) was significantly

SUBMITTER: Lu Y 

PROVIDER: S-EPMC8569246 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature