Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria.

ABSTRACT: Malaria is a major international public health problem that affects millions of patients worldwide especially in sub-Saharan Africa. Although many tests have been developed to diagnose malaria infections, we still lack reliable diagnostic biomarkers for the identification of disease severity, especially in endemic areas where the diagnosis of cerebral malaria is very difficult and requires the exclusion of all other possible causes. Previous host and pathogen transcriptomic studies have not yielded homogenous results that can be harnessed into a reliable diagnostic tool. Here we utilized a multi-cohort analysis approach using machine-learning algorithms to identify blood gene signatures that can distinguish severe and cerebral malaria from moderate and non-cerebral cases. Using a Regulariz

SUBMITTER: Omar M 

PROVIDER: S-EPMC8569259 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature