Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome.

ABSTRACT:

Background

Irritable bowel syndrome (IBS), the most common functional gastrointestinal disorder, is characterized by chronic abdominal pain and bowel habit changes. Although diverse complicated etiologies are involved in its pathogenesis, a dysregulated gut-brain axis may be an important factor. Red ginseng (RG), a traditional herbal medicine, is proven to have anti-inflammatory effects and improve brain function; however, these effects have not been investigated in IBS.

Methods

Three-day intracolonic zymosan injections were used to induce post-infectious human IBS-like symptoms in mice. The animals were randomized to receive either phosphate-buffered saline (CG) or RG (30/100/300 mg/kg) for 10 days. Amitriptyline and sulfasalazine were used as positive controls. Macroscopic

SUBMITTER: Yu S 

PROVIDER: S-EPMC8569328 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature