A retrospective study of the antibiotic-resistant phenotypes and genotypes of Helicobacter pylori strains in China.

ABSTRACT: Helicobacter pylori antibiotic resistance is a serious concern in China, where it severely influences treatment for H. pylori infection. To overcome this, it is essential to apply personalized therapies based on local or individual data on antibiotic-resistant phenotypes or genotypes. We conducted a large-scale multi-center study with a retrospective cross-sectional observational design to investigate the antibiotic-resistant phenotypes and genotypes of H. pylori in China. Strains were isolated from the gastric biopsy samples of H. pylori-infected patients from five different regions in China. The strains were tested for antibiotic-resistant phenotypes and genotypes, and the agreement between the two was assessed. In total, 4242 H. pylori strains were iso

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC8569369 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature