Clonal dynamics and clinical implications of postremission clonal hematopoiesis in acute myeloid leukemia.

ABSTRACT: Although clonal hematopoiesis (CH) can precede the development of acute myeloid leukemia (AML), it can also persist after achieving remission. Long-term clonal dynamics and clinical implications of persistent CH are not well understood. Here, we studied the prevalence, dynamics, and clinical implications of postremission CH in 164 AML patients who attained complete remission after induction chemotherapies. Postremission CH was identified in 79 (48%) patients. Postremission CH persisted long term in 91% of the trackable patients despite treatment with various types of consolidation and maintenance therapies. Postremission CH was eradicated in 20 out of 21 (95%) patients who underwent allogeneic stem cell transplant. Although patients with postremission CH as a group had comparable hematopoi

SUBMITTER: Tanaka T 

PROVIDER: S-EPMC8569418 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature