Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex.

ABSTRACT: Ginsenoside Rh2 (G‑Rh2) is a monomeric compound that extracted from ginseng and possesses anti‑cancer activities both in vitro and in vivo. Previously, we reported that G‑Rh2 induces apoptosis in HeLa cervical cancer cells and that the process was related to reactive oxygen species (ROS) accumulation and mitochondrial dysfunction. However, the upstream mechanisms of G‑Rh2, along with its cellular targets, remain to be elucidated. In the present study, the Cell Counting Kit‑8 assay, flow cytometry and Hoechst staining revealed that G‑Rh2 significantly inhibited cell viability and induced apoptosis of cervical cancer cells. However, G‑Rh2 was demonstrated to be non‑toxic to End1/e6e7 cells. JC‑1, rhodamine 123 staining, oxidative phosphorylation and glycolysis capacity assays d

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8569524 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature