The Prognostic Value of Bone Morphogenetic Proteins and Their Receptors in Lung Adenocarcinoma.

ABSTRACT:

Background

Bone morphogenetic proteins (BMPs) regulate tumor progression via binding to their receptors (BMPRs). However, the expression and clinical significance of BMPs/BMPRs in lung adenocarcinoma remain unclear due to a lack of systematic studies.

Methods

This study screened differentially expressed BMPs/BMPRs (deBMPs/BMPRs) in a training dataset combining TCGA-LUAD and GTEx-LUNG and verified them in four GEO datasets. Their prognostic value was evaluated via univariate and multivariate Cox regression analyses. LASSO was performed to construct an initial risk model. Subsequently, after weighted gene co-expression network analysis (WGCNA), differential expression analysis, and univariate Cox regression analysis, hub genes co-expressed with differentially exp

SUBMITTER: Meng W 

PROVIDER: S-EPMC8569625 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature