International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma.

ABSTRACT:

Background

The International Prognostic Index (IPI) is widely used to discriminate the prognosis of patients with diffuse large B-cell lymphoma (DLBCL). However, there is a significant need to identify novel valuable biomarkers in the context of targeted therapy, such as immune checkpoint blockade (ICB).

Methods

Gene expression data and clinical DLBCL information were obtained from The Cancer Genome Atlas and Gene Expression Omnibus datasets. A total of 371 immune-related genes in DLBCL patients associated with different IPI risk groups were identified by weighted gene co-expression network analysis, and eight genes were selected to construct an IPI-based immune prognostic model (IPI-IPM). Subsequently, we analyzed the somatic mutation and transcription profiles of the IPI-I

SUBMITTER: Mu S 

PROVIDER: S-EPMC8569825 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature