Serious adverse drug reactions in sub-Saharan Africa in the era of antiretroviral treatment: A systematic review.

ABSTRACT: We aimed to summarize and describe the burden of serious adverse drug reactions (ADRs) in sub-Saharan Africa (SSA) in the era of antiretroviral therapy. We searched Medline, CINAHL, Africa-Wide Information, Scopus, and Web of Science, without language restriction up to March 2021. We hand-searched reference lists, conference abstracts, and dissertation databases. We included studies reporting proportions of admissions attributed to ADRs, admissions prolonged by ADRs, or in-hospital deaths attributed to ADRs. Two reviewers independently screened the studies, reviewed the study quality using a previously published tool, and extracted the data. We tested for heterogeneity using I² -statistics and summarized the study results using medians and interquartile ranges. Subgroup analyses

SUBMITTER: Mouton JP 

PROVIDER: S-EPMC8569857 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature