Long-term behavioral effects observed in mice chronically exposed to static ultra-high magnetic fields.

ABSTRACT:

Purpose

The primary goal of this study was to investigate whether chronic exposures to ultra-high B₀ fields can induce long-term cognitive, behavioral, or biological changes in C57BL/6 mice.

Methods

C57BL/6 mice were chronically exposed to 10.5-T or 16.4-T magnetic fields (3-h exposures, two exposure sessions per week, 4 or 8 weeks of exposure). In vivo single-voxel ¹ H magnetic resonance spectroscopy was used to investigate possible neurochemical changes in the hippocampus. In addition, a battery of behavioral tests, including the Morris water-maze, balance-beam, rotarod, and fear-conditioning tests, were used to examine long-term changes induced by B₀ exposures.

Results

Hippocampal neurochemical profile, cognitive, and basic motor fu

SUBMITTER: Tkac I 

PROVIDER: S-EPMC8569931 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature