Extensive frontal focused ultrasound mediated blood-brain barrier opening for the treatment of Alzheimer's disease: a proof-of-concept study.

ABSTRACT:

Background

Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening has shown efficacy in removal of amyloid plaque and improvement of cognitive functions in preclinical studies, but this is rarely reported in clinical studies. This study was conducted to evaluate the safety, feasibility and potential benefits of repeated extensive BBB opening.

Methods

In this open-label, prospective study, six patients with Alzheimer's disease (AD) were enrolled at Severance Hospital in Korea between August 2020 and September 2020. Five of them completed the study. FUS-mediated BBB opening, targeting the bilateral frontal lobe regions over 20 cm³, was performed twice at three-month intervals. Magnetic resonance imaging, ¹⁸F-Florbetaben (FBB) positron emissio

SUBMITTER: Park SH 

PROVIDER: S-EPMC8570037 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature