Unknown

Dataset Information

0

Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Progresses and Challenges.


ABSTRACT: Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world and its incidence is increasing in many countries. In recent years, with the deepening understanding of the immune and pathological mechanisms of HCC, immunotherapy based on the regulation of tumor immune microenvironment has become a new treatment choice for patients with HCC. Immune checkpoint inhibitors (ICIs) targeting programmed death protein-1, programmed death protein-ligand-1, or cytotoxic T-lymphocyte-associated antigen 4 are the most widely used. Instead of general immune-enhancing therapies, ICIs can reactivate anti-tumor immune responses by disrupting co-inhibitory T cell signaling. In this review, the research progress and existing problems of ICIs in the treatment of HCC in recent years are reviewed.

SUBMITTER: Liu HT 

PROVIDER: S-EPMC8570111 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Progresses and Challenges.

Liu Hao-Tian HT   Jiang Meng-Jie MJ   Deng Zhu-Jian ZJ   Li Le L   Huang Jian-Li JL   Liu Zhen-Xiu ZX   Li Le-Qun LQ   Zhong Jian-Hong JH  

Frontiers in oncology 20211022


Hepatocellular carcinoma (HCC) is one of the most common malignant tumor in the world and its incidence is increasing in many countries. In recent years, with the deepening understanding of the immune and pathological mechanisms of HCC, immunotherapy based on the regulation of tumor immune microenvironment has become a new treatment choice for patients with HCC. Immune checkpoint inhibitors (ICIs) targeting programmed death protein-1, programmed death protein-ligand-1, or cytotoxic T-lymphocyte-  ...[more]

Similar Datasets

| S-EPMC6394775 | biostudies-literature
| S-EPMC7412709 | biostudies-literature
| S-EPMC7603151 | biostudies-literature
| S-EPMC9478417 | biostudies-literature
| S-EPMC6095178 | biostudies-literature
| S-EPMC7944520 | biostudies-literature
| S-EPMC8821949 | biostudies-literature
| S-EPMC7712941 | biostudies-literature
| S-EPMC9913409 | biostudies-literature
| S-EPMC10035682 | biostudies-literature