ESTROGEN RECEPTOR EXPRESSION ON BREAST CANCER PATIENTS' SURVIVAL UNDER SHAPE RESTRICTED COX REGRESSION MODEL.

ABSTRACT: For certain subtypes of breast cancer, study findings show that their level of estrogen receptor expression is associated with their risk of cancer death, and also suggests a non-linear effect on the hazard of death. A flexible form of the proportional hazards model, λ(t∣x, z ) = λ(t) exp( z ^T β )q(x), is desirable to facilitate a rich class of covariate effect on a survival outcome to provide meaningful insight, where the functional form of q(x) is not specified except for its shape. Prior biologic knowledge on the shape of the underlying distribution of the covariate effect in regression models can be used to enhance statistical inference. Despite recent progress, major cha

SUBMITTER: Qin J 

PROVIDER: S-EPMC8570133 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature