Redox Sensing Modulates the Activity of the ComE Response Regulator of Streptococcus mutans.

ABSTRACT: Streptococcus mutans, a dental pathogen, encodes the ComDE two-component system comprised of a histidine kinase (ComD) and a response regulator (ComE). This system is necessary for production of bacteriocins and development of genetic competence. ComE interacts with its cognate promoters to activate the transcription of bacteriocin and competence-related genes. Previous transcriptomic studies indicated that expressions of bacteriocin genes were upregulated in the presence of oxygen. To understand the relationship between the aerobic condition and bacteriocin expression, we analyzed the S. mutans ComE sequence and its close homologs. Surprisingly, we noticed the presence of cysteine (Cys) residues located at positions 200 and 229, which are highly conserved among the ComE homologs. Here, we

SUBMITTER: Dhaked HPS 

PROVIDER: S-EPMC8570269 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature