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On the Efficacy of and Preference for Signaling Extinction in a Multiple Schedule.

ABSTRACT: Previous basic research has shown that signaling the extinction component of a compound schedule can be aversive and nonpreferred. However, such discriminative stimuli are common when thinning schedules of reinforcement in practice, and they provide several advantages to clinicians. A limitation of previous applied studies on different arrangements of discriminative stimuli is that researchers have used identical stimuli to signal the availability of reinforcement across conditions that do and do not signal extinction, often doubling exposure to the stimulus signaling the availability of reinforcement. The present experiments corrected this limitation by comparing multiple-schedule arrangements that do and do not signal extinction when unique stimuli signal each component across conditions. Results from three participants indicated that both multiple-schedule arrangements were similarly efficacious when teaching the successive discrimination. However, response patterns differed when testing under a concurrent-operants arrangement, suggesting different patterns of preference across various multiple-schedule arrangements.

SUBMITTER: Odell AJ

PROVIDER: S-EPMC8570325 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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On the Efficacy of and Preference for Signaling Extinction in a Multiple Schedule.

Odell Alicia J AJ Greer Brian D BD Fuhrman Ashley M AM Hardee Alexandra M AM

Behavioral development bulletin 20210722 2

Previous basic research has shown that signaling the extinction component of a compound schedule can be aversive and nonpreferred. However, such discriminative stimuli are common when thinning schedules of reinforcement in practice, and they provide several advantages to clinicians. A limitation of previous applied studies on different arrangements of discriminative stimuli is that researchers have used identical stimuli to signal the availability of reinforcement across conditions that do and d ...[more]

PMID: 34745411

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Project description:Extinction learning refers to the phenomenon that a previously learned response to an environmental stimulus, for example the expression of an aversive behavior upon exposure to a specific context, is reduced when the stimulus is repeatedly presented in the absence of a previously paired aversive event. Extinction of fear memories has been implicated with the treatment of anxiety disease but the molecular processes that underlie fear extinctionare only beginning to emerge. Here we show that fear extinction initiates up-regulation of hippocampal insulin-growth factor 2 (Igf2) and down-regulation of insulin-growth factor binding protein 7 (Igfbp7). In line with this observation we demonstrate that IGF2 facilitates fear extinction, while IGFBP7 impairs fear extinction in an IGF2-dependent manner. Furthermore, we identify one cellular substrate of altered IGF2-signaling during fear extinction. To this end we show that fear extinction-induced IGF2/IGFBP7-signaling promotes the survival of 17-19 day-old newborn hippocampal neurons. In conclusion, our data suggests that therapeutic strategies that enhance IGF2-signaling and adult neurogenesis might be suitable to treat disease linked to excessive fear memory. We employed mice to investigate fear extinction in the hippocampus-dependent contextual fear conditioning paradigm. To this end, male C57BL/6J mice were exposed to the fear conditioning box (context) followed by an electric foot-shock which elicits the acquisition of conditioned contextual fear. For extinction training animals were repeatedly reexposed to the conditioned context on consecutive days (24h interval) without receiving the footshockagain (extinction trial, E). This procedure eventually results in the decline of the aversive freezing behavior. Mice that were exposed to the conditioning context without receiving fear conditioning training served as control groups. To gain a better understanding of the molecular processes underlying fear extinction we performed a genome-wide analysis of the hippocampal transcriptome during fear extinction. In the employed paradigm fear extinction is a gradual process. To capture the longitudinal course of fear extinction we decided to perform hippocampal microarray analysis at two time points: (1) After the first extinction trial (E1) when animals display high levels of aversive freezing behavior and (2) at the extinction trial on which the freezing behavior was significantly reduced when compared to E1. This extinction trial, in the case of this experiment E5, we termed “extinction trial low freezing” (ELF). Mice that were exposed to the conditioning context without receiving fear conditioning training served as control groups (3). For all three groups we hybridized 5 samples (biological replicates).

Dataset Information

On the Efficacy of and Preference for Signaling Extinction in a Multiple Schedule.

Publications

On the Efficacy of and Preference for Signaling Extinction in a Multiple Schedule.

Similar Datasets

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